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Actives are scientifically proven active ingredients. Prescription has selected the most effective actives and formulated them in the highest possible concentration and purest form. Actives are not serums. A pure active contains one or a few potent actives at high concentrations, without soothing additives like oils or hydrating ingredients that serums often include. As a result, a pure active may sometimes feel more watery, drying, or tingly. This is normal and indicates that the active ingredient is working directly and intensively on the skin.