Which ingredients can you combine in your skincare routine (and which not)?

Many people wonder if certain active ingredients can be used together. Consider combinations like retinol with vitamin C or AHAs with niacinamide. Combining actives can enhance each other's effects, but it can also lead to irritation or less effective results when ingredients interact.

Prescription keeps these choices clear. Our routines are created using the AI ​​Skin Scan and reviewed by experts like Dr. David Mosmuller , Dr. Tjinta Brinkhuizen , and skin therapist Sacha Sommers .

Why ingredient combinations can be challenging

• Ingredients can neutralize each other , reducing their effectiveness.
• Too many powerful actives at once can stress the skin barrier.
• Incorrect timing (morning vs. evening) can affect effectiveness.

A well-thought-out combination helps prevent irritation and keeps your routine effective.

Effective and safe combinations

Retinol + Niacinamide

Niacinamide supports the skin barrier and may reduce the chance of irritation from retinol.

Vitamin C + SPF

Vitamin C protects against free radicals; SPF protects against UV damage. Together, they create a powerful morning combination.

Hyaluronic acid + virtually every ingredient

Hyaluronic acid hydrates and fits into almost any routine because it rarely irritates.

Combinations that you should use with caution

Retinol + Vitamin C

Both are powerful actives. Combining them in a single routine can be too intense. Alternating AM/PM often works better.

AHA/BHA + Tretinoin or strong retinoids

This can lead to excessive exfoliation and irritation of the skin barrier.

Benzoyl peroxide + Vitamin C

Benzoyl peroxide can make vitamin C unstable, making it less effective.

Expert tips

• Dr. Tjinta Brinkhuizen: “Be careful with acids in combination with retinoids.”
• Sacha Sommers: “Go for proven and safe combinations — not for what’s trending on social media.”

How Prescription handles this

The AI ​​Skin Scan creates a personalized routine based on your skin type and skin conditions. The combinations are verified by dermatologists and skin therapists. This ensures that the ingredients you use support each other and can be used safely together.

Conclusion

Combining active ingredients doesn't have to be complicated, as long as you understand how certain substances interact. A well-developed routine helps prevent irritation and ensures that ingredients work optimally. Prescription offers personalized, expertly monitored routines that simplify these choices for you.

FAQ

Can I use retinol and vitamin C together?
Only if you divide them wisely: vitamin C in the morning and retinol in the evening.

What combines well with niacinamide?
Niacinamide works well with almost all actives and helps soothe the skin.

How do I know which combination is right for my skin?
The Prescription AI Skin Scan provides immediate insight into safe and effective combinations for your skin type.